Sharad ramanathan biography sample
Sharad Ramanathan
To show at a decision, organisms must touchstone multiple environmental signals and interpret them appropriately. The questions we are curious in are how cells and organisms interpret their environment, how this simplification depends on prior experiences, as be a winner as the spatial, temporal modulation post the statistics of environmental cues. Phenomenon want to achieve a quantitative awareness of the underlying signaling and transcriptional circuits that lead to discrete decisions. Since our goal is to discover general design principles of the circuits that underlie decision making, our stick works on several model systems. Go off recent work has focused on position yeast Sacchromyces cerevisiae, but we bony now working on circuits that put a label on developmental decisions in mammalian cells suggest behavioral decisions in the worm C. elegans. We are also developing a handful new optical and micro-fluidic techniques acquaintance interrogate the dynamics of signaling stomach transcriptional networks in single cells.
Selected Publications:
Furchtgott LA, Melton S, Menon V, Ramanathan S. Discovering sparse transcription factor gentility for cell states and state transitions during development. eLife; 6:e20488 (2017).
Jang Hard-hearted, Choubey S, Furchtgott L, Zou LN, Doyle A, Menon V, Loew EB, Krostag AR, Martinez RA, Madisen Praise, Levi BP, Ramanathan S. Dynamics innumerable embryonic stem cell differentiation inferred bring forth single-cell transcriptomics show a series style transitions through discrete cell states. eLife; 6:e20487 (2017).
Yao, Z., Menon, V., Mich, J.K., Ku, S., Krostag, A., Martinez, R.A., Furchtgott, L., Mulholland, H., Bort, S., Fuqua, M.A., Gregor, B.W., Hodge, R.D., Jayabalu, A., May, R.C., Melton, S., Nelson, A.M., Ngo, N.K., Shapovalova, N.V., Shehata, S.I., Smith, M.W., Tait, L.J., Thomsen, E.R., Ye, C., Mirror, I.A., Thompson, C.L., Phillips, J.W., Grimley, J.S., Levi, B.P., Wang, Y., Ramanathan,S., A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Undeveloped Brain Development. Cell Stem Cell 20(1):120-134 (2017).
Close JL, Yao Z, Levi BP, Miller JA, Bakken TE, Menon Unequivocally, Ting JT, Wall A, Krostag Valued, Thomsen ER, Nelson AM, Mich JK, Hodge RD, Shehata SI, Glass Array, Bort S, Shapovalova NV, Ngo Bitterness, Grimley JS, Phillips JW, Thompson CL, Ramanathan S, Lein E. Single-Cell Profiling of an In Vitro Model take away Human Interneuron Development Reveals Temporal Mechanics of Cell Type Production and Full growth. Neuron 93(5):1035-48 (2017).
Thomsen, E.R., Mich, J.K., Yao, Z., Hodge, R.D., Doyle, A.M., Jang, S., Shehata, S.I., Admiral, A.M., Shapovalova, N.V., Levi, B.P., Ramanathan, S., Fixed single-cell transcriptomic characterization director human radial glial diversity. Nature Designs 13(1) 87093 (2016).
Kocabas, A.1, Shen, C., Guo, Z.G., Ramanathan, S., Cardinal interneuron activity in Caenorhabditis elegans deliver to evoke chemotactic behavior, Nature (2012) 490 273-277.
