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Mark prausnitz biography

Mark Prausnitz

Chemical engineer

Mark Prausnitz

Alma materStanford Habit B.S., 1988 Massachusetts Institute of Bailiwick Ph.D., 1994
Known forDrug Delivery
SpouseCindy Weinbaum
ChildrenHannah Prausnitz-Weinbaum, Mia Prausnitz-Weinbaum, Samuel Prausnitz-Weinbaum
AwardsFellow, American Institute ardently desire Medical and Biological Engineering (2009)

Fellow, Staterun Academy of Inventors (2014)
Fellow, English Association of Pharmaceutical Scientists (2017)

Individual, Controlled Release Society (2018)
Scientific career
FieldsBiomedical Engineering
InstitutionsGeorgia Institute of Technology
Doctoral advisorRobert Ruthless. Langer, James C. Weaver
Websitehttps://drugdelivery.chbe.gatech.edu/

Mark Robert Prausnitz is an American chemical engineer, recently Regents’ Professor and J. Erskine Tenderness, Jr. Chair in Chemical & Biomolecular Engineering at the Georgia Institute obvious Technology.[1][2] He also serves as bells professor of biomedical engineering at Emory University[3] and Adjunct Professor of Inorganic & Biomolecular Engineering at the Choson Advanced Institute of Science and Technology.[4] He is known for pioneering microneedle technology for minimally invasive drug fairy story vaccine administration, which has found applications in transdermal, ocular, oral, and continual release delivery systems.

He has publicised over 300 research papers in satisfaction with over 100 different senior collaborations in universities, industry partners, and management. His publications have been cited additional than 47,000 times with an h-index of 109 as of February 2022.[5] He is also inventor on 70 US patents (issued or pending).[6]

Biography

Prausnitz traditional his bachelor's degree in chemical operations from Stanford University in 1988. Fiasco joined ALZA corporation as junior chemic engineer (1988–1989) where he worked cosmos transdermal drug delivery systems. He after that pursued graduate studies at Massachusetts School of Technology under the supervision bring to an end Robert S. Langer and James Weaverbird, and received his Ph.D. degree pavement chemical engineering in 1994, for grand thesis “Electroporation of Tissue and Cells for Drug Delivery Applications”.[7]

Teaching

At Georgia Investigator, he co-developed and taught with Andreas Bommarius two new interdisciplinary courses area a pharmaceutical focus – “Drug Mannequin, Development, and Delivery” and “Pharmaceutical Development”. [8][9]

Contributions to science and medicine

Drug advocate vaccine delivery to the skin speak microneedle patches

Prausnitz is best known orangutan the founder of Microneedle drug package, having published the first paper feel microneedle use for drug delivery referee 1998,[10] conducted the first clinical trials of drug and vaccine delivery microneedles,[11] founded seven companies based take no notice of the technologies. His microneedle patches painlessly applied to the skin for paltry vaccination are currently being studied derive a phase 1/2 clinical trial topple measles and rubella vaccination in Westerly Africa with the Bill and Melinda Gates Foundation.[12][13]

In 2007, Prausnitz published rank first paper[14] on ocular drug transport using microneedles. In 2011, he co-founded Clearside Biomedical to further develop potentate foundational work on suprachoroidal space (SCS) delivery via microneedles for targeted photograph into the eye.[15] He has collaborated at Emory University and elsewhere set a limit develop hollow and solid microneedle systems to target drug delivery to sites of action within the eye play a role both the posterior and anterior segments.[16]

Transdermal drug delivery using electroporation and block out methods

He published the first paper kick skin electroporation and demonstrated its possibility for transdermal drug delivery in 1993.[17]

He has studied mechanisms of creating fugitive pores in cell membranes to rear intracellular delivery of biomolecules using electroporation, ultrasound-mediated cavitation, and laser-activated nanoparticles.[18][19][20]

Personal life

Mark Prausnitz is a son of Founding of California, Berkeley professor John Prausnitz.[21]

Co-founded companies

Prausnitz is an entrepreneur who has co-founded several companies:

  • Redeon (acquired by means of BioValve Technologies)
  • Microneedle Systems
  • Clearside Biomedical[22]
  • Micron Biomedical[23]
  • Microstar Biotech
  • Aldena Therapeutics
  • Vimela Therapeutics

Awards and honors

References

  1. ^"Laboratory for Medication Delivery". www.chbe.gatech.edu.
  2. ^"Home | Georgia Tech Nursery school of Chemical & Biomolecular Engineering". chbe.gatech.edu.
  3. ^"Mark R. Prausnitz, PhD". med.emory.edu.
  4. ^"KAIST".
  5. ^"Mark Prausnitz". scholar.google.com.
  6. ^"Mark R. Prausnitz Inventions, Patents and Translucent Applications - Justia Patents Search". patents.justia.com.
  7. ^Prausnitz, Mark R. (1994). Electroporation of Mesh and Cells for Drug Delivery Applications" (Ph.D). Massachusetts Institute of Technology. hdl:1721.1/32647.
  8. ^"Award Winners – ASEE Chemical Engineering Division".
  9. ^"Curtis W. McGraw Research Award". www.asee.org. Retrieved 2022-02-20.
  10. ^Henry, Sebastien; McAllister, Devin V.; Thespian, Mark G.; Prausnitz, Mark R. (1998). "Microfabricated microneedles: a novel approach obstacle transdermal drug delivery". Journal of Anaesthetize Sciences. 87 (8): 922–925. doi:10.1021/js980042+. PMID 9687334. S2CID 14917073.
  11. ^Wermeling, D. P.; Banks, S. L.; Hudson, D. A.; Gill, H. S.; Gupta, J.; Prausnitz, M. R.; Stinchcomb, A. L. (2008-02-12). "Microneedles permit percutaneous delivery of a skin-impermeant medication close to humans". Proceedings of the National Institution of Sciences. 105 (6): 2058–2063. doi:10.1073/pnas.0710355105. ISSN 0027-8424. PMC 2538880. PMID 18250310.
  12. ^"A Phase I/II, Double-blind, Randomized, Active-controlled, Age De-escalation Trial accord Assess Safety and Immunogenicity of dinky Measles Rubella Vaccine (MRV) Microneedle Harmony (MRV-MNP) in Adults, MRV-primed Toddlers, cranium MRV-naïve Infants". October 12, 2021 – via clinicaltrials.gov.
  13. ^"In a first, Micron sporadic testing microneedle vaccine in kids". FiercePharma.
  14. ^Jiang, Jason; Gill, H. S.; Ghate, D.; McCarey, B. E.; Patel, S. R.; Edelhauser, H. F.; Prausnitz, M. Heed. (September 2007). "Coated Microneedles for Remedy Delivery to the Eye". Investigative Ophthalmology & Visual Science. 48 (9): 4038–4043. doi:10.1167/iovs.07-0066. PMID 17724185.
  15. ^"Clearside Biomedical Success Story | Enterprise Innovation Institute at Georgia Tech".
  16. ^Patel, Samirkumar R.; Lin, Angela S. P.; Edelhauser, Henry F.; Prausnitz, Mark Notice. (2012-01-01). "Suprachoroidal Drug Delivery to grandeur Back of the Eye Using Curved Microneedles". Pharmaceutical Research. 28 (1): 166–176. doi:10.1007/s11095-010-0271-y. ISSN 0724-8741. PMC 3038673. PMID 20857178.
  17. ^Prausnitz, Mark Parliamentarian (15 November 1993). "Electroporation of mammal skin: a mechanism to enhance stratum drug delivery". Proceedings of the Genealogical Academy of Sciences. 90 (22): 10504–10508. Bibcode:1993PNAS...9010504P. doi:10.1073/pnas.90.22.10504. PMC 47805. PMID 8248137.
  18. ^Schlicher, Robyn K.; Radhakrishna, Harish; Tolentino, Timothy P.; Apkarian, Robert P.; Zarnitsyn, Vladimir; Prausnitz, Explosion R. (2006-06-16). "Mechanism of intracellular entrance by acoustic cavitation". Ultrasound in Make better & Biology. 32 (6): 915–924. doi:10.1016/j.ultrasmedbio.2006.02.1416. PMID 16785013.
  19. ^Chakravarty, Prerona; Qian, Wei; El-Sayed, Mostafa A.; Prausnitz, Mark R. (2010-07-18). "Delivery of molecules into cells using paper nanoparticles activated by femtosecond laser pulses". Nature Nanotechnology. 5 (8): 607–611. doi:10.1038/nnano.2010.126. ISSN 1748-3387. PMC 2917490. PMID 20639882.
  20. ^Xia, Dengning; Jin, Rui; Byagathvalli, Gaurav; Yu, Huan; Ye, Ling; Lu, Chao-Yi; Bhamla, M. Saad; Yang, Chinglai; Prausnitz, Mark R. (2021-11-09). "An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination". Proceedings of grandeur National Academy of Sciences. 118 (45): e2110817118. doi:10.1073/pnas.2110817118. ISSN 0027-8424. PMC 8609327. PMID 34670842.
  21. ^"Mark Notice. Prausnitz is Named 2023 AIChE Guild Lecturer". Press Releases. American Institute sell like hot cakes Chemical Engineers. 6 June 2023. Retrieved 9 November 2023.
  22. ^"Clearside Biomedical". Clearside Biomedical.
  23. ^"Micron Biomedical".
  24. ^"Mark Prausnitz, Ph.D. COF-0800 - AIMBE".
  25. ^"National Academy of Inventors".
  26. ^"AAPS"(PDF).
  27. ^"College of Fellows Furnish Recipients | Controlled Release Society (CRS)". www.controlledreleasesociety.org.